Approximately 1 billion people in the world suffer from neurological disorders, defined as progressive loss of neurological functions, including dementia, stroke, multiple sclerosis, epilepsy, migraines, brain injuries, cancer, and neuroinfections. The neurodegenerative disorders include Alzheimer’s disease; the tremor-associated Parkinson’s disease, caused by death of dopaminergic neurons; amyotrophic lateral sclerosis, involving neuronal death and loss of motor function; the inherited disorder Huntington’s disease; and multiple sclerosis, an immune-mediated disorder affecting myelination of neuronal axons.

The Human Protein Atlas (www.proteinatlas.org) is an open-access database containing RNA and protein profiles of all genes across cells, tissues, and organs in the human body. The new Brain Atlas subsection contains genome-wide RNA profiles of all human protein–coding genes found in human, pig, and mouse brains. These profiles are complemented by antibody-based protein localization data collected for selected protein targets in the human and mouse brain.

During this webinar, the speakers will:

• Introduce the Brain Atlas and how its data was generated
• Discuss the process for identification and characterization of both brain- and regional-specific proteins and how they overlap
• Explain the two different strategies for profiling proteins in the human and mouse brain.

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